Article Environmental Sciences
Prenatal exposure to per- and polyfluoroalkyl substances and cognitive development in infancy and toddlerhood
Jiwon Oh, Rebecca J. Schmidt, Daniel Tancredi, Antonia M. Calafat, Dorcas L. Roa, Irva Hertz-Picciotto, Hyeong-Moo Shin
Summary: This study revealed that prenatal maternal serum perfluorooctanoate (PFOA) concentrations were inversely associated with child's cognitive development in infancy and toddlerhood, particularly at 24 and 36 months. While other five PFAS showed weak associations with cognitive development, PFOA exhibited significant negative effects on both the overall cognitive scores and specific subscales.
ENVIRONMENTAL RESEARCH (2021)
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Article Environmental Sciences
Lead Exposure in Infancy and Subsequent Growth in Beninese Children
Shukrullah Ahmadi, Jeremie Botton, Romeo Zoumenou, Pierre Ayotte, Nadine Fievet, Achille Massougbodji, Maroufou Jules Alao, Michel Cot, Philippe Glorennec, Florence Bodeau-Livinec
Summary: This study found that elevated blood lead levels were associated with childhood stunting and a smaller head circumference in a resource-limited setting. No overall association was found between blood lead levels and other growth outcomes.
TOXICS (2022)
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Article Medicine, General & Internal
Prenatal Lead Exposure, Genetic Factors, and Cognitive Developmental Delay
Zhenxian Jia, Hongling Zhang, Ling Yu, Feng Qiu, Yiqing Lv, Jing Guan, Huiqing Gang, Jingwen Zuo, Tongzhang Zheng, Hongxiu Liu, Wei Xia, Shunqing Xu, Yuanyuan Li
Summary: This prospective cohort study found an association between prenatal lead exposure and increased risk of cognitive developmental delay (CDD) in children with high genetic risk. These findings suggest that prenatal lead exposure and genetic background may jointly contribute to an increased risk of CDD in children, indicating the possibility for an integrated strategy to assess CDD risk and improve children's cognitive ability.
JAMA NETWORK OPEN (2023)
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Article Psychology, Developmental
Effects of prenatal opioid exposure on functional networks in infancy
Stephanie L. Merhar, Weixiong Jiang, Nehal A. Parikh, Weiyan Yin, Zhen Zhou, Jean A. Tkach, Li Wang, Beth M. Kline-Fath, Lili He, Adebayo Braimah, Jennifer Vannest, Weili Lin
Summary: Prenatal opioid exposure in infants has been associated with differences in network connectivity, particularly in terms of betweenness centrality and connection length, with unique connections in the opioid-exposed group more often being inter-network compared to intra-network connections. The opioid-exposed group also showed smaller network volumes in the primary visual network, but similar network strength as controls, indicating potential neural basis for developmental and visual problems associated with prenatal opioid exposure.
DEVELOPMENTAL COGNITIVE NEUROSCIENCE (2021)
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Article Virology
Cortical Auditory Evoked Potentials in Children with Prenatal Exposure to Zika Virus
Lais Cristine Delgado da Hora, Lilian Ferreira Muniz, Leonardo Gleygson Angelo Venancio, Karina Paes Advincula, Jessica Dayane da Silva, Diana Babini Lapa de Albuquerque Britto, Democrito de Barros Miranda Filho, Elizabeth B. Brickley, Ricardo Arraes de Alencar Ximenes, Silvio da Silva Caldas Neto, Mariana de Carvalho Leal
Summary: Prenatal exposure to ZIKV can have negative effects on auditory pathways, but CAEP testing can reveal preserved neural function. MRI results show structural changes in the brains of microcephalic children, but CAEP results indicate that these children still have some ability to process sound stimuli.
VIRUSES-BASEL (2022)
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Article Pediatrics
Neurodevelopment in normocephalic children with and without prenatal Zika virus exposure
Karen Blackmon, Roberta Evans, Michelle Fernandes, Barbara Landon, Trevor Noel, Calum Macpherson, Nikita Cudjoe, Kemi S. Burgen, Bianca Punch, Amy Krystosik, Elysse N. Grossi-Soyster, Angelle Desiree LaBeaud, Randall Waechter
Summary: Neurodevelopmental outcomes were compared between ZIKV-exposed children with normal head circumference at birth and a control group, showing that overall neurodevelopment is likely unaffected in the exposed group, but the visual system may be selectively vulnerable, indicating the importance of vision testing by 3 years of age.
ARCHIVES OF DISEASE IN CHILDHOOD (2022)
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Article Environmental Sciences
Prenatal lead exposure, telomere length in cord blood, and DNA methylation age in the PROGRESS prenatal cohort
Jose F. Herrera-Moreno, Guadalupe Estrada-Gutierrez, Haotian Wu, Tessa R. Bloomquist, Maria Jose Rosa, Allan C. Just, Hector Lamadrid-Figueroa, Martha M. Tellez-Rojo, Robert O. Wright, Andrea A. Baccarelli
Summary: This study aimed to investigate the associations of prenatal lead exposures with telomere length and DNA-methylation-based predictors of age in cord blood, but no significant associations were found.
ENVIRONMENTAL RESEARCH (2022)
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Article Biochemistry & Molecular Biology
Behavioral and neurochemical effects in mice after one-generation exposure to low doses of manganese: Focus on offspring development
Amandia R. Batschauer, Tugstenio L. Souza, Patricia E. Manuitt Brito, Francisco Filipak Neto, Ciro A. Oliveira Ribeiro, Claudia F. Ortolani-Machado
Summary: The study found that chronic perinatal exposure to low doses of manganese in mice can lead to neurotoxic effects, including memory impairment and increased anxiety-like behavior. Manganese exposure also affects biochemical markers in different brain regions, indicating that exposure to low doses of manganese may be harmful to a generation.
CHEMICO-BIOLOGICAL INTERACTIONS (2021)
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Article Biology
Prenatal development of neonatal vocalizations
Darshana Z. Narayanan, Daniel Y. Takahashi, Lauren M. Kelly, Sabina Hlavaty, Junzhou Huang, Asif A. Ghazanfar
Summary: Human and non-human primates produce rhythmical sounds as soon as they are born to solicit the attention of caregivers. This study shows, through dense and longitudinal sampling of fetal head and orofacial movements in marmoset monkeys, that the orofacial movements necessary for producing rhythmical vocalizations differentiate from larger movement patterns and that signature features of marmoset infant contact calls emerge prenatally as a distinct pattern of orofacial movements.
ELIFE (2022)
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Article Cell Biology
Transgenerational Effects of Prenatal Ethanol Exposure in Prepubescent Mice
Riley T. Bottom, Olga O. Kozanian, David J. Rohac, Michael A. Erickson, Kelly J. Huffman
Summary: This study used a transgenerational mouse model to investigate the effects of prenatal ethanol exposure on offspring behavior. The results suggest that behavioral abnormalities can be passed down to multiple generations. However, the specific brain mechanisms underlying these behavioral changes remain unclear.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)
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Review Pediatrics
Prenatal exposure to opioids and neurodevelopment in infancy and childhood: A systematic review
Arin A. A. Balalian, Richard Graeve, Matthias Richter, Astrid Fink, Heike Kielstein, Silvia S. S. Martins, Morgan M. M. Philbin, Pam Factor-Litvak
Summary: This systematic review aims to estimate the relationship between prenatal exposure to opioids and neurodevelopmental outcomes. Data from 79 studies showed that prenatal opioid exposure generally had negative effects on cognitive and motor skills as well as behavior. However, significant heterogeneity among studies in terms of assessment methods and participant recruitment prevented a meta-analysis.
FRONTIERS IN PEDIATRICS (2023)
Article Environmental Sciences
Prenatal lead exposure and cord blood DNA methylation in the Korean Exposome Study
Jaehyun Park, Jeeyoung Kim, Esther Kim, Woo Jin Kim, Sungho Won
Summary: Prenatal lead exposure was found to be associated with altered, gender-specific patterns of DNA methylation in Korean infants. In males, maternal blood lead level during early pregnancy was linked to 18 CpG sites, while a CpG site near the NBAS gene was associated during late pregnancy. No significant association was observed in females.
ENVIRONMENTAL RESEARCH (2021)
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Review Medicine, General & Internal
Prenatal Methamphetamine Exposure: Effects on Child Development A Systematic Review
Lorenz Harst, Stefanie Deckert, Frederik Haarig, Joerg Reichert, Juergen Dinger, Peter Hellmund, Jochen Schmitt, Mario Ruediger
Summary: The systematic review focused on the effects of prenatal methamphetamine exposure (PME) on child development, showing that PME is associated with lower birth weight, shorter body length, smaller head circumference, as well as psychological and neurocognitive abnormalities. Some differences persist into toddler years, especially in children growing up in problematic environments.
DEUTSCHES ARZTEBLATT INTERNATIONAL (2021)
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Article Pediatrics
Prenatal antidepressant exposure and child development at kindergarten age: a population-based study
Mina Park, Gillian E. Hanley, Martin Guhn, Tim F. Oberlander
Summary: The study found that prenatal antidepressant exposure was associated with increased anxious behaviors and lower physical independence in children at kindergarten age, but had no significant effects on other developmental domains. These effects are likely attributable to the severity of underlying maternal mood disorders, emphasizing the importance of maternal mental health for developmental outcomes.
PEDIATRIC RESEARCH (2021)
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Article Pediatrics
Prenatal cannabinoid exposure and early language development
Maria M. Talavera-Barber, Evlyn Morehead, Katherine Ziegler, Christine Hockett, Amy J. Elliott
Summary: This study explores the association between prenatal cannabis exposure and neurodevelopmental outcomes at 12 months of age. The results show that infants exposed to cannabis demonstrate increased expressive and receptive language scores at 12 months, which may have positive implications for their performance in school.
FRONTIERS IN PEDIATRICS (2023)
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Article Urology & Nephrology
Evidence of Novel Susceptibility Variants for Prostate Cancer and a Multiancestry Polygenic Risk Score Associated with Aggressive Disease in Men of African Ancestry
Fei Chen, Ravi K. Madduri, Alex A. Rodriguez, Burcu F. Darst, Alisha Chou, Xin Sheng, Anqi Wang, Jiayi Shen, Edward J. Saunders, Suhn K. Rhie, Jeannette T. f Bensen, Sue A. Ingles, Rick A. Kittles, Sara S. Strom, Benjamin A. Rybicki, Barbara Nemesure, William B. Isaacs, Janet L. Stanford, Wei Zheng, Maureen Sanderson, Esther M. John, Jong Y. Park, Jianfeng Xu, Ying Wang, Sonja I. Berndt, Chad D. Huff, Edward D. Yeboah, Yao Tettey, Joseph Lachance, Wei Tang, Christopher T. Rentsch, Kelly Cho, Benjamin H. Mcmahon, Richard B. Biritwum, Andrew A. Adjei, Evelyn Tay, Ann Truelove, Shelley Niwa, Thomas A. Sellers, Kosj Yamoah, Adam B. Murphy, Dana C. Crawford, Alpa V. Patel, William S. Bush, Melinda C. Aldrich, Olivier Cussenot, Gyorgy Petrovics, Jennifer Cullen, Christine M. Neslund-Dudas, Mariana C. Stern, Zsofia Kote-Jarai, Koveela Govindasami, Michael B. Cook, Anand P. Chokkalingam, Ann W. Hsing, Phyllis J. Goodman, Thomas J. Hoffmann, Bettina F. Drake, Jennifer J. Hu, Jacob M. Keaton, Jacklyn N. Hellwege, Peter E. Clark, Mohamed Jalloh, Serigne M. Gueye, Lamine Niang, Olufemi Ogunbiyi, Michael O. Idowu, Olufemi Popoola, Akindele O. Adebiyi, Oseremen I. Aisuodionoe-Shadrach, Hafees O. Ajibola, Mustapha A. Jamda, Olabode P. Oluwole, Maxwell Nwegbu, Ben Adusei, Sunny Mante, Afua Darkwa-Abrahams, James E. Mensah, Halimatou Diop, Stephen K. Van Den Eeden, Pascal Blanchet, Jay H. Fowke, Graham Casey, Anselm J. Hennis, Alexander Lubwama, Ian M. Thompson, Robin Leach, Douglas F. Easton, Michael H. Preuss, Ruth J. Loos, Susan M. Gundell, Peggy Wan, James L. Mohler, Elizabeth T. Fontham, Gary J. Smith, Jack A. Taylor, Shiv Srivastava, Rosaline A. Eeles, John D. Carpten, Adam S. Kibel, Luc Multigner, Marie-Elise Parent, Florence Menegaux, Geraldine Cancel-Tassin, Eric A. Klein, Caroline Andrews, Timothy R. Rebbeck, Laurent Brureau, Stefan Ambs, Todd L. Edwards, Stephen Watya, Stephen J. Chanock, John S. Witte, William J. Blot, J. Michael Gaziano, Amy C. Justice, David Conti, Christopher A. Haiman
Summary: In this study, a large-scale genetic analysis was conducted in men of African ancestry, leading to the discovery of nine novel risk variants for prostate cancer (PCa). Furthermore, a multiancestry polygenic risk score was developed to effectively stratify PCa risk and differentiate the risk of aggressive and nonaggressive disease.
EUROPEAN UROLOGY (2023)
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Article Environmental Sciences
Prenatal and childhood chlordecone exposure, cognitive abilities and problem behaviors in 7-year-old children: the TIMOUN mother-child cohort in Guadeloupe
Youssef Oulhote, Florence Rouget, Leah Michineau, Christine Monfort, Mireille Desrochers-Couture, Jean-Pierre Thome, Philippe Kadhel, Luc Multigner, Sylvaine Cordier, Gina Muckle
Summary: This study aimed to assess the effects of prenatal and postnatal exposure to chlordecone on cognitive and behavioral functions in children. The results found that blood concentrations of chlordecone in children were associated with lower IQ scores and increased externalizing behavior problems. Additionally, higher concentrations of chlordecone in cord blood were related to greater internalizing behavioral problems, especially in girls.
ENVIRONMENTAL HEALTH (2023)
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Article Obstetrics & Gynecology
Serum persistent organic pollutants and diminished ovarian reserve: a single-exposure and mixture exposure approach from a French case-control study
M. Genard-Walton, C. Warembourg, S. Duros, F. Mercier, T. Lefebvre, A. Guivarc'h-Leveque, M-T Le Martelot, B. Le Bot, B. Jacquemin, C. Chevrier, S. Cordier, N. Costet, L. Multigner, R. Garlantezec
Summary: This study found that p,p'-DDE was significantly associated with an increased risk of diminished ovarian reserve (DOR), while beta-hexachlorocyclohexane (beta-HCH) was significantly associated with a decreased risk of DOR. Mixture analyses did not detect any interactions between persistent organic pollutants (POPs).
HUMAN REPRODUCTION (2023)
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Article Environmental Sciences
Persistent organochlorine pesticides in periprostatic adipose tissue from men with prostate cancer: Ethno-geographic variations, association with disease aggressiveness
Jean-Philippe Antignac, Sandy Figiel, Michele Pinault, Pascal Blanchet, Franck Bruyere, Romain Mathieu, Souhil Lebdai, Georges Fournier, Jerome Rigaud, Karine Maheo, Philippe Marchand, Ingrid Guiffard, Emmanuelle Bichon, Bruno le Bizec, Luc Multigner, Gaelle Fromont
Summary: This study investigated the association between OCPs concentrations in PPAT and prostate cancer aggressiveness, and found significant ethno-geographic variation in exposure. Most OCPs were positively correlated with age and BMI, while mirex showed an inverse association with aggressive features of PCa.
ENVIRONMENTAL RESEARCH (2023)
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Article Obstetrics & Gynecology
Heavy metals and diminished ovarian reserve: single-exposure and mixture analyses amongst women consulting in French fertility centres
Maximilien Genard-Walton, Charline Warembourg, Solene Duros, Martine Ropert-Bouchet, Tiphaine Lefebvre, Anne Guivarch-Leve, Marie-Therese Le Martelot, Benedicte Jacquemin, Sylvaine Cordier, Nathalie Costet, Luc Multigner, Ronan Garlantezec
Summary: The study found weak signals that certain heavy metals may be associated with diminished ovarian reserve (DOR), but further research is needed to confirm these findings.
REPRODUCTIVE BIOMEDICINE ONLINE (2023)
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Article Genetics & Heredity
Evaluating approaches for constructing polygenic risk scores for prostate cancer in men of African and European ancestry
Burcu F. Darst, Jiayi Shen, Ravi K. Madduri, Alexis A. Rodriguez, Yukai Xiao, Xin Sheng, Edward J. Saunders, Tokhir Dadaev, Mark N. Brook, Thomas J. Hoffmann, Kenneth Muir, Peggy Wan, Loic Le Marchand, Lynne Wilkens, Ying Wang, Johanna Schleutker, Robert J. MacInnis, Cezary Cybulski, David E. Neal, Borge G. Nordestgaard, Sune F. Nielsen, Jyotsna Batra, Judith A. Clements, Henrik Gronberg, Nora Pashayan, Ruth C. Travis, Jong Y. Park, Demetrius Albanes, Stephanie Weinstein, Lorelei A. Mucci, David J. Hunter, Kathryn L. Penney, Catherine M. Tangen, Robert J. Hamilton, Marie-Elise Parent, Janet L. Stanford, Stella Koutros, Alicja Wolk, Karina D. Sorensen, William J. Blot, Edward D. Yeboah, James E. Mensah, Yong-Jie Lu, Daniel J. Schaid, Stephen N. Thibodeau, Catharine M. West, Christiane Maier, Adam S. Kibel, Geraldine Cancel-Tassin, Florence Menegaux, Esther M. John, Eli Marie Grindedal, Kay-Tee Khaw, Sue A. Ingles, Ana Vega, Barry S. Rosenstein, Manuel R. Teixeira, Manoli Kogevinas, Lisa Cannon-Albright, Chad Huff, Luc Multigner, Radka Kaneva, Robin J. Leach, Hermann Brenner, Ann W. Hsing, Rick A. Kittles, Adam B. Murphy, Christopher J. Logothetis, Susan L. Neuhausen, William B. Isaacs, Barbara Nemesure, Anselm J. Hennis, John Carpten, Hardev Pandha, Kim De Ruyck, Jianfeng Xu, Azad Razack, Soo-Hwang Teo, Lisa F. Newcomb, Jay H. Fowke, Christine Neslund-Dudas, Benjamin A. Rybicki, Marija Gamulin, Nawaid Usmani, Frank Claessens, Manuela Gago-Dominguez, Jose Esteban Castelao, Paul A. Townsend, Dana C. Crawford, Gyorgy Petrovics, Graham Casey, Monique J. Roobol, Jennifer F. Hu, Sonja I. Berndt, Stephen K. van den Eeden, Douglas F. Easton, Stephen J. Chanock, Michael B. Cook, Fredrik Wiklund, John S. Witte, Rosalind A. Eeles, Zsofia Kote-Jarai, Stephen Watya, John M. Gaziano, Amy C. Justice, David V. Conti, Christopher A. Haiman
Summary: In this study, the predictive ability of several genome-wide polygenic risk score (GW-PRS) approaches was compared to a recently developed PRS of established prostate cancer-risk variants. The findings suggest that the PRS269 developed from multi-ancestry GWASs and fine-mapping has better predictive ability for prostate cancer risk compared to current GW-PRS approaches.
AMERICAN JOURNAL OF HUMAN GENETICS (2023)
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Review Engineering, Environmental
A Critical Review on the Opportunity to Use Placenta and Innovative Biomonitoring Methods to Characterize the Prenatal Chemical Exposome
Thomas Contini, Remi Beranger, Luc Multigner, Jana Klanova, Elliott J. Price, Arthur David
Summary: The adverse effects of chemical exposures during pregnancy, including developmental and reproductive disorders, are likely underestimated. Using high-resolution mass spectrometry on placenta shows potential for improving the monitoring of chemical exposure during pregnancy. Further investigations are needed to standardize placental sampling and consider other variables such as collection time, fetal sex, and mode of delivery.
ENVIRONMENTAL SCIENCE & TECHNOLOGY (2023)
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Article Oncology
Performance of African-ancestry-specific polygenic hazard score varies according to local ancestry in 8q24
Roshan A. Karunamuni, Minh-Phuong Huynh-Le, Chun C. Fan, Wesley Thompson, Asona Lui, Maria Elena Martinez, Brent S. Rose, Brandon Mahal, Rosalind A. Eeles, Zsofia Kote-Jarai, Kenneth Muir, Artitaya Lophatananon, Catherine M. Tangen, Phyllis J. Goodman, Ian M. Thompson, William J. Blot, Wei Zheng, Adam S. Kibel, Bettina F. Drake, Olivier Cussenot, Geraldine Cancel-Tassin, Florence Menegaux, Therese Truong, Jong Y. Park, Hui-Yi Lin, Jack A. Taylor, Jeannette T. Bensen, James L. Mohler, Elizabeth T. H. Fontham, Luc Multigner, Pascal Blanchet, Laurent Brureau, Marc Romana, Robin J. Leach, Esther M. John, Jay H. Fowke, William S. Bush, Melinda C. Aldrich, Dana C. Crawford, Jennifer Cullen, Gyorgy Petrovics, Marie-Elise Parent, Jennifer J. Hu, Maureen Sanderson, Ian G. Mills, Ole A. Andreassen, Anders M. Dale, Tyler M. Seibert
Summary: This study used principal component analysis to uncover subpopulations of men with African ancestry for whom the utility of PHS46+African may differ. The results revealed that PHS46+African may be up to 7 times more beneficial to some African men than others. Further research is needed to improve the clinical utility of polygenic risk scores for men of African ancestry.
PROSTATE CANCER AND PROSTATIC DISEASES (2022)
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Article Toxicology
Chlordecone: development of a physiologically based pharmaco*kinetic tool to support human health risks assessments
Claude Emond, Luc Multigner
Summary: This study developed a physiologically based pharmaco*kinetic (PBPK) model in rats and extrapolated it to humans, aiming to improve health risk assessments for CD contamination and reassess toxicological reference values.
ARCHIVES OF TOXICOLOGY (2022)
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Article Health Care Sciences & Services
Inverse probability weighting to handle attrition in cohort studies: some guidance and a call for caution
Marie-Astrid Metten, Nathalie Costet, Luc Multigner, Jean-Francois Viel, Guillaume Chauvet
Summary: The study compared the IPW method with complete-case analysis (CCA) for nine response-mechanism scenarios, finding that the IPW method was equivalent to CCA in terms of bias and consistently less efficient in all scenarios. It was concluded that the most effective response model included only the confounding factors of the association model.
BMC MEDICAL RESEARCH METHODOLOGY (2022)
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Article Urology & Nephrology
A Rare Germline HOXB13 Variant Contributes to Risk of Prostate Cancer in Men of African Ancestry
Burcu F. Darst, Raymond Hughley, Aaron Pfennig, Ujani Hazra, Caoqi Fan, Peggy Wan, Xin Sheng, Lucy Xia, Caroline Andrews, Fei Chen, Sonja Berndt, Zsofia Kote-Jarai, Koveela Govindasami, Jeannette T. Bensen, Sue A. Ingles, Benjamin A. Rybicki, Barbara Nemesure, Esther M. John, Jay H. Fowke, Chad D. Huff, Sara S. Strom, William B. Isaacs, Jong Y. Park, Wei Zheng, Elaine A. Ostrander, Patrick C. Walsh, John Carpten, Thomas A. Sellers, Kosj Yamoah, Adam B. Murphy, Maureen Sanderson, Dana C. Crawford, Susan M. Gapstur, William S. Bush, Melinda C. Aldrich, Olivier Cussenot, Gyorgy Petrovics, Jennifer Cullen, Christine Neslund-Dudas, Rick A. Kittles, Jianfeng Xu, Mariana C. Stern, Anand P. Chokkalingam, Luc Multigner, Marie-Elise Parent, Florence Menegaux, Geraldine Cancel-Tassin, Adam S. Kibel, Eric A. Klein, Phyllis J. Goodman, Janet L. Stanford, Bettina F. Drake, Jennifer J. Hu, Peter E. Clark, Pascal Blanchet, Graham Casey, Anselm J. M. Hennis, Alexander Lubwama, Ian M. Thompson, Robin J. Leach, Susan M. Gundell, Loreall Pooler, James L. Mohler, Elizabeth T. H. Fontham, Gary J. Smith, Jack A. Taylor, Laurent Brureau, William J. Blot, Richard Biritwum, Evelyn Tay, Ann Truelove, Shelley Niwa, Yao Tettey, Rohit Varma, Roberta McKean-Cowdin, Mina Torres, Mohamed Jalloh, Serigne Magueye Gueye, Lamine Niang, Olufemi Ogunbiyi, Michael Oladimeji Idowu, Olufemi Popoola, Akindele O. Adebiyi, Oseremen Aisuodionoe-Shadrach, Maxwell Nwegbu, Ben Adusei, Sunny Mante, Afua Darkwa-Abrahams, Edward D. Yeboah, James E. Mensah, Andrew Anthony Adjei, Halimatou Diop, Michael B. Cook, Stephen J. Chanock, Stephen Watya, Rosalind A. Eeles, Charleston W. K. Chiang, Joseph Lachance, Timothy R. Rebbeck, David Conti, Christopher A. Haiman
Summary: A specific germline deletion variant in HOXB13 (X285K) was found to be associated with an increased risk of prostate cancer in men of West African ancestry. This variant was more strongly associated with aggressive and advanced disease. Understanding who carries this variant can inform prostate cancer screening in men of West African ancestry.
EUROPEAN UROLOGY (2022)
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Article Neurosciences
Visuospatial processing and fine motor function among 7-years old Guadeloupe children pre- and postnatally exposed to the organochlorine pesticide chlordecone
Mireille Desrochers-Couture, Sylvaine Cordier, Florence Rouget, Leah Michineau, Christine Monfort, Jean-Pierre Thome, Philippe Kadhel, Luc Multigner, Gina Muckle
Summary: This study aimed to investigate whether the effects of prenatal exposure to chlordecone persist until middle childhood and whether deleterious effects are observed in the domain of visual processing. Associations with postnatal exposure and sex-specific vulnerabilities were also examined.
NEUROTOXICOLOGY (2022)
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Article Endocrinology & Metabolism
Metabolic syndrome and prostate cancer in Afro-Caribbean men
Florian Lefebvre, Anne Blanchet-Deverly, Leah Michineau, Pascal Blanchet, Luc Multigner, Laurent Brureau
Summary: This study aimed to assess the prevalence of metabolic syndrome among Afro-Caribbean prostate cancer patients and its association with adverse clinicopathological features and biochemical recurrence risk. The results showed a high variability in metabolic syndrome prevalence depending on the obesity criteria used, and no significant association was found between metabolic syndrome and prostate cancer outcomes. Further studies with strict and uniform criteria are encouraged to clarify the association between metabolic syndrome and prostate cancer outcomes.
PROSTATE (2022)
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Article Oncology
Prostate cancer risk stratification improvement across multiple ancestries with new polygenic hazard score
Minh-Phuong Huynh-Le, Roshan Karunamuni, Chun Chieh Fan, Lui Asona, Wesley K. Thompson, Maria Elena Martinez, Rosalind A. Eeles, Zsofia Kote-Jarai, Kenneth R. Muir, Artitaya Lophatananon, Johanna Schleutker, Nora Pashayan, Jyotsna Batra, Henrik Groenberg, David E. Neal, Borge G. Nordestgaard, Catherine M. Tangen, Robert J. MacInnis, Alicja Wolk, Demetrius Albanes, Christopher A. Haiman, Ruth C. Travis, William J. Blot, Janet L. Stanford, Lorelei A. Mucci, Catharine M. L. West, Sune F. Nielsen, Adam S. Kibel, Olivier Cussenot, Sonja Berndt, Stella Koutros, Karina Dalsgaard Sorensen, Cezary Cybulski, Eli Marie Grindedal, Florence Menegaux, Jong Y. Park, Sue A. Ingles, Christiane Maier, Robert J. Hamilton, Barry S. Rosenstein, Yong-Jie Lu, Stephen Watya, Ana Vega, Manolis Kogevinas, Fredrik Wiklund, Kathryn L. Penney, Chad D. Huff, Manuel R. Teixeira, Luc Multigner, Robin J. Leach, Hermann Brenner, Esther M. John, Radka Kaneva, Christopher J. Logothetis, Susan L. Neuhausen, Kim De Ruyck, Piet Ost, Azad Razack, Lisa F. Newcomb, Jay H. Fowke, Marija Gamulin, Aswin Abraham, Frank Claessens, Jose Esteban Castelao, Paul A. Townsend, Dana C. Crawford, Gyorgy Petrovics, Ron H. N. van Schaik, Marie-Elise Parent, Jennifer J. Hu, Wei Zheng, Ian G. Mills, Ole A. Andreassen, Anders M. Dale, Tyler M. Seibert
Summary: This study evaluates the effect of using single-nucleotide polymorphisms (SNPs) for prostate cancer risk stratification, and finds that including additional SNPs improves the association with clinically significant prostate cancer in multi-ancestry datasets. This is promising for implementing precision-medicine approaches to prostate cancer screening decisions in diverse populations.
PROSTATE CANCER AND PROSTATIC DISEASES (2022)
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Article Neurosciences
Neuroinflammation and white matter alterations in occupational manganese exposure assessed by diffusion basis spectrum imaging
Susan R. Criswell, Susan Searles Nielsen, Irene M. Faust, Joshua S. Shimony, Robert L. White III, Jason Lenox-Krug, Brad A. Racette
Summary: This study evaluated the neuroinflammation and white matter microstructural integrity in individuals with occupational manganese exposure. The findings showed that welders with manganese exposure had higher indicators of neuroinflammation-related cellularity, greater extracellular edema, and lower apparent axonal density in multiple white matter tracts, suggesting a neuroinflammatory component in the pathophysiology of manganese neurotoxicity.
NEUROTOXICOLOGY (2023)
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Article Neurosciences
Sex-specific associations between maternal phthalate exposure and neurodevelopmental outcomes in children at 2 years of age in the APrON cohort
Deborah Dewey, Jonathan W. Martin, Amy M. MacDonald, David W. Kinniburgh, Nicole Letourneau, Gerald F. Giesbrecht, Catherine J. Field, Rhonda C. Bell, Gillian England-Mason
Summary: This study aimed to evaluate the associations between prenatal phthalate exposure and sex-specific outcomes on children's neurodevelopment. The results showed that higher concentrations of DEHP phthalates in boys were associated with poorer cognition, language, and motor skills, while in girls, higher DEHP exposure was associated with more executive function and behavior problems. Limited associations were observed between phthalate mixtures and sex-specific neurodevelopmental outcomes.
NEUROTOXICOLOGY (2023)
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Article Neurosciences
Impact of manganese accumulation on Na,K-ATPase expression and function in the cerebellum and striatum of C57Bl/6 mice
Larisa V. Smolyaninova, Yulia A. Timoshina, Daniil S. Berezhnoy, Tatiana N. Fedorova, Ivan V. Mikheev, Irina F. Seregina, Nadezhda A. Loginova, Maxim G. Dobretsov
Summary: In a mouse model of manganism, exposure to manganese led to learning and motor disturbances in the cerebellum, accompanied by decreased activity of NKA and increased expression of α1-α3 isoforms. These findings suggest that disruptions in the expression and activity of NKA in the cerebellum and striatum may not directly contribute to the early behavioral deficits observed in manganism.
NEUROTOXICOLOGY (2023)
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Article Neurosciences
ALDH2 inhibition by lead and ethanol elicits redox imbalance and mitochondrial dysfunction in SH-SY5Y human neuroblastoma cell line: Reversion by Alda-1
Romina Deza-Ponzio, Paula A. Albrecht, Lucia E. Fernandez-Hubeid, Tuany Eichwald, Romina B. Cejas, Yohana C. Garay, Mario Rivera-Meza, Alexandra Latini, Fernando J. Irazoqui, Miriam B. Virgolini
Summary: Combined exposure to Pb and EtOH impairs ALDH2 functionality, leading to mitochondrial dysfunction and increased oxidative stress. NAD+ or an ALDH2 enhancer can restore ALDH2 activity and alleviate the detrimental effects.
NEUROTOXICOLOGY (2023)
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Article Neurosciences
Assessing CaMPARI as new approach methodology for evaluating neurotoxicity
Dana Biechele-Speziale, Manuel Camarillo, Nathan R. Martin, John Biechele-Speziale, Pamela J. Lein, Jessica S. Plavicki
Summary: Developmental exposure to environmental toxicants can cause neurological disorders, but there are still knowledge gaps in understanding the cellular targets and molecular mechanisms involved. Zebrafish is a useful model for neurotoxicology due to its genetic similarity to humans. Behavioral assays alone cannot predict the effects of chemical exposures on brain structures and cell types. Integrating behavioral assays with imaging techniques such as CaMPARI provides a more comprehensive understanding of neurotoxic endpoints and offers a high-throughput approach to toxicity testing.
NEUROTOXICOLOGY (2023)
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Article Neurosciences
Resistance physical exercise alleviates lipopolysaccharide-triggered neuroinflammation in cortex and hippocampus of rats via purinergic signaling
Vanessa Valeria Miron, Charles Elias Assmann, Vitor Bastianello Mostardeiro, Nathieli Bianchin Bottari, Jucimara Baldissarelli, Karine Paula Reichert, Anielen Dutra da Silva, Milagros Fanny Vera Castro, Loren Borba de Jesus, Marcylene Vieira da Silveira, Tais Vidal Palma, Vera Maria Morsch, Andreia Machado Cardoso, Maria Rosa Chitolina Schetinger
Summary: Resistance physical exercise has been found to have neuroprotective and anti-inflammatory effects on various diseases. This study investigated the enzymes and components of the purinergic system that play a role in the inflammatory process mediated by P2X7R. The results showed that resistance exercise prevented the increase of inflammatory markers and purinergic system components. The findings suggest that modulation of P2X7R through resistance physical exercise could be a potential strategy for managing inflammatory-related illnesses.
NEUROTOXICOLOGY (2023)
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Article Neurosciences
Social deficits in mice prenatally exposed to valproic acid are intergenerationally inherited and rescued by social enrichment
Cecilia Zappala, Claudio Dario Barrios, Amaicha Mara Depino
Summary: The effects of valproic acid (VPA) prenatal exposure on autism spectrum disorder (ASD)-related behavioral phenotypes can be transmitted to the F2 generation through the paternal lineage, but not transgenerationally. Male F2 individuals show reduced sociability, which can be rescued by social enrichment. Female behavior is not affected by VPA exposure, and there is no evidence of maternal transmission of the consequences of this pharmacological treatment. The VPA model of ASD is a valuable mouse model to study epigenetic inheritance and its underlying mechanisms affecting behavior and neuronal function.
NEUROTOXICOLOGY (2023)
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Article Neurosciences
Zinc (Zn) and adipose-derived mesenchymal stem cells (AD-MSCs) on MPTP-induced Parkinson's disease model: A comparative evaluation of behavioral and immunohistochemical results
Sendegul Yildirim, Ece Oylumlu, Ayse Ozkan, Osman Sinen, Mehmet Bulbul, Ethem Taner Goksu, Mustafa Gokhan Ertosun, Gamze Tanriover
Summary: Parkinson's disease is characterized by the loss of dopamine neurons and sustained neuroinflammation. Adipose tissue-derived mesenchymal stem cells (AD-MSCs) can secrete neuroprotective factors and zinc has immunomodulatory functions. Our study showed that AD-MSC and zinc treatment improved motor impairment and increased TH and BDNF expression in dopaminergic neurons in a MPTP-induced mouse model of PD.
NEUROTOXICOLOGY (2023)
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Article Neurosciences
Developmental exposure of zebrafish to neonicotinoid pesticides: Long-term effects on neurobehavioral function
Andrew B. Hawkey, Dilanaz Unal, Zade R. Holloway, Edward D. Levin
Summary: This study evaluated the neurobehavioral effects of two neonicotinoid insecticides on zebrafish during embryonic exposure. The results showed that low concentrations of these insecticides affected the locomotion of larvae, while higher concentrations affected the activity and predator avoidance ability of adult fish. These effects were persistent and continued into adulthood.
NEUROTOXICOLOGY (2023)
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Article Neurosciences
An efficient cellular image-based platform for high-content screening of neuroprotective agents against chemotherapy-induced neuropathy
Yang-Chen Chang, Yi-Ching Lo, Hsun-Shuo Chang, Hui-Ching Lin, Chien-Chih Chiu, Yih-Fung Chen
Summary: Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting side effect with no approved prevention or treatment. This study established a high-content image platform using DRG-derived neuron cells to discover neuroprotective agents against pacl*taxel-induced CIPN. The results showed that pacl*taxel disrupted neurite outgrowth in the differentiated ND7/23 DRG cells, similar to pacl*taxel's effects on primary cultured DRG neurons. This study demonstrated that high-content analyses of well-differentiated DRG neuron-derived cells provide an effective strategy for developing therapeutics against CIPN.
NEUROTOXICOLOGY (2023)
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Article Neurosciences
Association of urinary heavy metals co-exposure and adult depression: Modification of physical activity
Xihang Fu, Huiru Li, Lingling Song, Manqiu Cen, Jing Wu
Summary: This study aimed to evaluate the association between urinary heavy metal mixture exposure and depression, and the modifying role of physical activity in the effects of heavy metal mixture on depression risk was also considered. The results showed that urinary tin and antimony were associated with an increased risk of depression, and physical activity could mitigate the effects of heavy metal co-exposure on depression risk.
NEUROTOXICOLOGY (2023)
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Review Neurosciences
Methylmercury effects on avian brains
Claire L. J. Bottini, Scott A. MacDougall-Shackleton
Summary: Methylmercury (MeHg) is a concerning contaminant due to its ubiquity and harmful effects on organisms. The literature on MeHg effects on the avian brain is limited, and the neural effects of MeHg exposure in birds have changed with time and researcher interest. Measures of oxidative stress were most consistently affected by MeHg exposure in birds. NMDA, acetylcholinesterase, and Purkinje cells also seem to be sensitive to MeHg exposure. Additional research is needed to validate the effects of MeHg on neurotransmitter systems in birds.
NEUROTOXICOLOGY (2023)
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Article Neurosciences
Multiple low-dose radiation-induced neuronal cysteine transporter expression and oxidative stress are rescued by N-acetylcysteine in neuronal SH-SY5Y cells
Ji-Young Yoo, Ye-Ji Lee, Yu-Jin Kim, Tai-Kyoung Baik, Jun-Ho Lee, Mi-Jo Lee, Ran-Sook Woo
Summary: Recently, studies have shown that low-dose radiation therapy is effective in treating Alzheimer's disease. It suppresses neuroinflammation and improves cognitive function. However, the direct effects of low-dose radiation on neuronal cells and the mechanisms involved are still not fully understood.
NEUROTOXICOLOGY (2023)
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Article Neurosciences
Developmental cadmium exposure disrupts zebrafish vestibular calcium channels interfering with otolith formation and inner ear function
Adrian J. Green, Alex R. Wall, Ryan D. Weeks, Carolyn J. Mattingly, Kurt C. Marsden, Antonio Planchart
Summary: It is estimated that dizziness or balance problems affect around 3.3 million children aged three to 17 years old. These disorders result from a disruption in the balance control system and can be caused by any factor that affects the inner ear or the brain, including exposure to environmental toxicants. Cadmium, an extremely toxic metal, has been linked to balance and vestibular dysfunction in adults exposed occupationally, but its developmental effects on low concentration exposure are not well understood. Our research shows that zebrafish exposed to cadmium concentrations of 10-60 parts per billion (ppb) from four hours post-fertilization to seven days post-fertilization exhibit abnormal behaviors, including increased auditory sensitivity and circling behavior. These behaviors are associated with reduced otolith growth and can be rescued by adding calcium to the media. Activation of the P2X calcium ion channel in the presence of cadmium restores normal otolith size.
NEUROTOXICOLOGY (2023)
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Article Neurosciences
Locomotion and brain gene expression exhibit sex-specific non-monotonic dose-response to HFPO-DA during Drosophila melanogaster lifespan
Jeanne P. Vu, Flannery McLamb, Zuying Feng, Lindsey Griffin, Sylvia Gong, Damian Shea, Mary A. Szuch, Savannah Scott, Richard M. Gersberg, Goran Bozinovic
Summary: The study found that the newer polymerization aid, HFPO-DA, does not accumulate in fruit flies and has sex-specific effects on lifespan, locomotion, and brain gene expression.
NEUROTOXICOLOGY (2023)
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